Design of Synthetic Strategies towards Sulfur Containing Scaffolds

Sambasivarao Kotha; Priti Khedkar

doi:10.1055/s-0043-1775393

Synthesis, Table of Contents

Synthesis 2025; 57(02): 275-295
DOI: 10.1055/s-0043-1775393

review

Special Topic Dedicated to Prof. H. Ila

Design of Synthetic Strategies towards Sulfur Containing Scaffolds

Sambasivarao Kotha∗

^aDepartment of Chemistry, Sunandan Divatia School of Science, SVKM’s NMIMS (Deemed-to-Be) University, Vile Parle (W), Mumbai, Maharashtra 400056, India

,

Priti Khedkar

^bDepartment of Chemistry, Guru Nanak Khalsa College of Arts, Science and Commerce (Autonomous), Matunga, Mumbai, Maharashtra, 400019, India

› Author Affiliations

Abstract

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Abstract

The utilization of sulfur heterocycles in organic synthesis has attracted significant attention due to their wide-ranging applications. This review showcases the syntheses of diverse sulfur heterocycles embedded with amino acid derivatives, polycycles, spirocycles, cyclophanes, and other complex scaffolds. The reported methods extend beyond compound synthesis and highlight the use of different sulfur reagents for constructing sulfur heterocycles. This Review also discusses the utility of a variety of sulfur-containing starting materials for the generation of complex target molecules.

1 Introduction

2 Potassium Thioacetate

3 Thiazolidine-2,4-dione

4 Rhodanines

5 Sodium Sulfide

6 Thiotetronic Acid

7 Thiadiazoles

8 Thiophene

9 Rongalite

10 Sulfur Dioxide

11 Divinyl Sulfone

12 Sulfur Heterocycles Based on Boronic Acids

13 Miscellaneous

14 Summary

Key words

sulfur heterocycles - potassium thioacetate - thiazolidine-2,4-dione - rhodanines - thiotetronic acid - thiadiazole - thiophene - rongalite

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