Abstract
Visible light photoredox and weak Brønsted base dual catalysis has emerged as a powerful
and versatile tool in the activation of C(sp3)–H bonds under mild reaction conditions. This method allows for the selective functionalization
of a wide range of substrates, including amines, sulfides, ethers, dithianes and dithiolanes,
dioxolanes, and alkenes. By exploiting the increased acidity of C–H bonds following
single electron oxidation, this strategy employing a dual catalyst facilitates various
carbon–carbon bond-forming reactions, as well as selective rearrangements, with high
efficiency and regioselectivity. This review highlights recent advancements in this
field, emphasizing the underlying mechanisms and the broad applicability of these
methodologies in organic synthesis.
1 Introduction
2 Activation of α-C(sp3)–H Bonds in N-, S-, and O-Containing Compounds for C–C Bond Formation
3 Activation of Allylic C–H Bonds for C–C Bond Formation
4 Photoredox and Base Dual Catalysis for Rearrangement Reactions
5 Conclusion
Key words
photoredox - weak Brønsted base - dual catalysis - single electron oxidation - C(sp
3)–H bond activation
