Harnessing Photoredox and Weak Brønsted Base Dual Catalysis for Selective C(sp3)–H Bond Activation

Shafrizal R. Atriardi; Yulia Anita; Sang Kook Woo

doi:10.1055/s-0043-1775423

Synthesis, Inhaltsverzeichnis

Synthesis 2025; 57(05): 953-964
DOI: 10.1055/s-0043-1775423

short review

Dual Catalysis

Harnessing Photoredox and Weak Brønsted Base Dual Catalysis for Selective C(sp³)–H Bond Activation

Autoren

Shafrizal R. Atriardi

^aDepartment of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, Busan 46241, Korea
Yulia Anita∗

^bResearch Center for Chemistry, National Research and Innovation Agency, 452 Build, Banten, 15314, Indonesia
Sang Kook Woo ∗

^aDepartment of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, Busan 46241, Korea

Abstract

Alle Artikel dieser Rubrik

Abstract

Visible light photoredox and weak Brønsted base dual catalysis has emerged as a powerful and versatile tool in the activation of C(sp³)–H bonds under mild reaction conditions. This method allows for the selective functionalization of a wide range of substrates, including amines, sulfides, ethers, dithianes and dithiolanes, dioxolanes, and alkenes. By exploiting the increased acidity of C–H bonds following single electron oxidation, this strategy employing a dual catalyst facilitates various carbon–carbon bond-forming reactions, as well as selective rearrangements, with high efficiency and regioselectivity. This review highlights recent advancements in this field, emphasizing the underlying mechanisms and the broad applicability of these methodologies in organic synthesis.

1 Introduction

2 Activation of α-C(sp³)–H Bonds in N-, S-, and O-Containing Compounds for C–C Bond Formation

3 Activation of Allylic C–H Bonds for C–C Bond Formation

4 Photoredox and Base Dual Catalysis for Rearrangement Reactions

5 Conclusion

Key words

photoredox - weak Brønsted base - dual catalysis - single electron oxidation - C(sp³)–H bond activation

Volltext

Referenzen

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