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CC BY 4.0 · Journal of Health and Allied Sciences NU 2024; 14(04): 477-485
DOI: 10.1055/s-0043-1777836
Original Article

Xylopia aethiopica Attenuates Oxidative Stress and Hepatorenal Damage in Testosterone Propionate-Induced Benign Prostatic Hyperplasia in Rats

Udu A. Ibiam
1   Department of Biochemistry, Faculty of Science, Ebonyi State University, Abakaliki, Ebonyi State, Nigeria
2   Department of Biochemistry, College of Science, Evangel University Akaeze, Ebonyi State, Nigeria
,
Daniel E. Uti 
3   Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, Federal University of Health Sciences, Otukpo, Benue State, Nigeria
,
Chris C. Ejeogo
1   Department of Biochemistry, Faculty of Science, Ebonyi State University, Abakaliki, Ebonyi State, Nigeria
,
Obasi U. Orji
1   Department of Biochemistry, Faculty of Science, Ebonyi State University, Abakaliki, Ebonyi State, Nigeria
,
Patrick M. Aja
1   Department of Biochemistry, Faculty of Science, Ebonyi State University, Abakaliki, Ebonyi State, Nigeria
,
Ezeaani N. Nwamaka
1   Department of Biochemistry, Faculty of Science, Ebonyi State University, Abakaliki, Ebonyi State, Nigeria
,
Esther U. Alum
1   Department of Biochemistry, Faculty of Science, Ebonyi State University, Abakaliki, Ebonyi State, Nigeria
8   Department of Research Publication and Extensions, Kampala International University, Main Campus, Uganda
,
Chukwuma Chukwu
4   Department of Chemistry, Alex Ekwueme Federal University, Ndufu-Alike Ikwo, Abakaliki, Ebonyi State, Nigeria
,
Chinyere Aloke
5   Department of Chemistry/Biochemistry and Molecular Biology, Alex Ekwueme Federal University, Ndufu-Alike Ikwo, Abakaliki, Ebonyi State, Nigeria
,
Matthew O. Itodo
3   Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, Federal University of Health Sciences, Otukpo, Benue State, Nigeria
,
Samuel A. Agada
3   Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, Federal University of Health Sciences, Otukpo, Benue State, Nigeria
,
Grace U. Umoru
2   Department of Biochemistry, College of Science, Evangel University Akaeze, Ebonyi State, Nigeria
,
Uket N. Obeten
5   Department of Chemistry/Biochemistry and Molecular Biology, Alex Ekwueme Federal University, Ndufu-Alike Ikwo, Abakaliki, Ebonyi State, Nigeria
,
Valentine O.G. Nwobodo
1   Department of Biochemistry, Faculty of Science, Ebonyi State University, Abakaliki, Ebonyi State, Nigeria
,
Solomon K. Nwadum
6   Department of Pharmacology and Therapeutics, Faculty of Clinical Basic Medicine, Ebonyi State University Abakaliki, Nigeria
,
Mfon P. Udoudoh
7   Department of Basic Sciences, Federal College of Medical Laboratory Science and Technology, Jos
› Author Affiliations Source of Funding This research was supported by the Ebonyi State University Tertiary Education Trust-fund Institutional Based Seed Research grants, 2020. Reference Number: EBSU/TETfund/IBR/2020/001.
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Abstract

Objectives Xylopia aethiopica (XAE), commonly known as African pepper or Ethiopian pepper, is a plant native to West Africa and known for its aromatic and medicinal properties. It was used to investigate the antioxidative, antihepatotoxic, and antinephrotoxic potentials of XAE in benign prostatic hyperplasia (BPH) in Wister albino rats.

Methods The proximate, and vitamin composition, oxidative stress indicators, and indices of kidney and hepatic functions were performed by standard methods.

Results The proximate composition of the XAE leaf showed varied concentrations of Mg, Ca, Na, Zn, Se, and Cl, as well as vitamins A, E, B3, D, C, K, B2, and Bi. The activities of catalase glutathione, superoxide dismutase, malondialdehyde levels, K, Na, Cl−, urea, uric acid, and creatinine in the kidney were increased in testosterone propionate (Tp)-induced BPH compared with the control groups. Total protein levels significantly decreased in Tp-induced BPH compared with XAE-treated groups increased on XAE treatment. The aspartate transaminase, alanine aminotransferase, and alkaline phosphatase activities were not significantly different in Tp-induced BPH, XAE, and normal controls.

Conclusion The study revealed that XAE can be used in the management of oxidative stress and hepatorenal damage in BPH condition.

Keywords

benign prostatic hyperplasia - Xylopia aethiopica - oxidative stress - hepato-renal damage - minerals

Authors' Contributions

U.A.I. conceived the study; D.E.U., C.C.E., O.U.O conducted literature searches; P.M.A., E.N.N., E.U.A. conducted data analysis; C.C., C.A., M.O.I., S.A.A., G.U.U., and V.N. wrote the original draft; U.A.I., D.E.U., and P.M.A. read and approved the final draft before submission. All authors have critically reviewed and approved the final draft of the manuscript.


Ethical Approval

The animal experimental methodology was performed in compliance with the precautions for the care and use of laboratory animals that Ebonyi State University Abakaliki, Ebonyi State (EBSU/ET/18/001) prescribed and approved.




Publication History

Article published online:
26 March 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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