Download PDF
CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2024; 34(03): 533-538
DOI: 10.1055/s-0044-1778727
Case Series

Additional Role of 3D ASL Perfusion in Skull Base Lesions

J. Fairoze Naghath 
1   Department of Radiodiagnosis, Barnard Institute of Radiology, Madras Medical College, Chennai, Tamil Nadu, India
,
S. Babu Peter 
1   Department of Radiodiagnosis, Barnard Institute of Radiology, Madras Medical College, Chennai, Tamil Nadu, India
› Author Affiliations Funding None.
› Further Information
Also available at
   Permissions and Reprints

Abstract

Background Arterial spin labeling (ASL) perfusion imaging is widely used since its main advantage is that no intravenous contrast is needed. Given that perfusion is a crucial biological characteristic for identifying tumor lesions, the qualitative noncontrast perfusion characteristics of these lesions were examined.

Aim We attempted utilizing the three-dimensional (3D) ASL technique to characterize skull base lesions and to highlight its crucial role in differentiating lesions.

Methods and Material 3D ASL imaging of 20 patients with posterior skull base lesions was performed in a 3-T magnetic resonance (MR) system (Siemens Healthineers, Skyra, Erlangen, Germany). The common differential diagnoses of skull base lesions could be distinguished based on this qualitative evaluation.

Results and Conclusions Glomus tumor has a strikingly increased perfusion when compared to meningiomas. The perfusion characteristics of metastasis depends on the primary tumor. Chondrosarcomas have a heterogeneously increased perfusion. Chordomas have variable perfusion, which helps in prognosticating the tumors. ASL benefits pediatric patients and in renal failure as well since it avoids the ethical ambiguity associated with contrast agents.

Keywords

arterial spin labeling - chondrosarcoma - glomus tumor - meningioma

Availability of Data and Material

The data are taken solely from our institution.


Authors' Contributions

J.F.N. did the major writeup of this case series. The majority of the cases in this review article were diagnosed by S.B.P. and followed up by J.F.N. The work was carried under the guidance of S.B.P. who provided us with insight and knowledge to diagnose indeterminate lesions with imaging alone.




Publication History

Article published online:
27 January 2024

© 2024. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Fujima N, Kudo K, Tsukahara A. et al. Measurement of tumor blood flow in head and neck squamous cell carcinoma by pseudo-continuous arterial spin labeling. Comparison With Dynamic Contrast-Enhanced MRI J Magn Reson Imaging 2015; 41: 983-991
    PubMedSearch in Google Scholar
  • 2 Grade M, Hernandez Tamames JA, Pizzini FB, Achten E, Golay X, Smits M. A neuroradiologist's guide to arterial spin labeling MRI in clinical practice. Neuroradiology 2015; 57 (12) 1181-1202
    CrossrefPubMedSearch in Google Scholar
  • 3 Kimura H, Takeuchi H, Koshimoto Y. et al. Perfusion imaging of meningioma by using continuous arterial spin-labeling: comparison with dynamic susceptibility-weighted contrast-enhanced MR images and histopathologic features. Am J Neuroradiol 2006; 27 (01) 85-93
    PubMedSearch in Google Scholar
  • 4 Jiang J, Zhao L, Zhang Y. et al. Comparative analysis of arterial spin labeling and dynamic susceptibility contrast perfusion imaging for quantitative perfusion measurements of brain tumors. Int J Clin Exp Pathol 2014; 7 (06) 2790-2799
    PubMedSearch in Google Scholar
  • 5 Abe T, Mizobuchi Y, Sako W. et al. Clinical significance of discrepancy between arterial spin labeling images and contrast-enhanced images in the diagnosis of brain tumors. Magn Reson Med Sci 2015; 14 (04) 313-319
    CrossrefPubMedSearch in Google Scholar
  • 6 Haller S, Zaharchuk G, Thomas DL, Lovblad KO, Barkhof F, Golay X. Arterial spin labeling perfusion of the brain: emerging clinical applications. Radiology 2016; 281 (02) 337-356
    CrossrefPubMedSearch in Google Scholar