Download PDF
CC BY 4.0 · Journal of Health and Allied Sciences NU 2024; 14(04): 579-582
DOI: 10.1055/s-0044-1779017
Case Report

Extensive Xanthomatous Change in an Ovarian Serous Borderline Tumor: More Than Just a Mere Coincidence

Aakanksha Koul 
1   Department of Pathology, Dr. Chandramma Dayananda Sagar Institute of Medical Education & Research, Dayananda Sagar University, Ramanagara, Karnataka, India
,
Archana Shetty 
1   Department of Pathology, Dr. Chandramma Dayananda Sagar Institute of Medical Education & Research, Dayananda Sagar University, Ramanagara, Karnataka, India
,
Hima Sree Edupuganti 
1   Department of Pathology, Dr. Chandramma Dayananda Sagar Institute of Medical Education & Research, Dayananda Sagar University, Ramanagara, Karnataka, India
,
Vijaya Mysorekar 
1   Department of Pathology, Dr. Chandramma Dayananda Sagar Institute of Medical Education & Research, Dayananda Sagar University, Ramanagara, Karnataka, India
› Author Affiliations
› Further Information
Also available at
   Permissions and Reprints

Abstract

Serous borderline tumors of the ovary fall in between the benign and malignant category. These tumors are often diagnosed early, and the prognosis is usually favorable. However, there are variations in the histopathological findings of borderline ovarian tumors. Xanthomatous change is one such rare change in which deposition of lipid-rich material is seen morphologically as xanthoma cells within tumor tissue and reports of this are sparse. There is postulated literature on xanthomatous change being a contributing factor for progression of cancer. We present a case of a 75-year-old postmenopausal female with complaint of pain abdomen since 3 days, diagnosed radiologically as right ovarian mucinous cystadenoma/cystadenocarcinoma. Histopathology revealed a serous borderline tumor with extensive xanthomatous change. This case presents important thoughts on exploring the connection of xanthomatous change with borderline ovarian tumors, which till date is a matter of debate.

Keywords

malignancy - ovary - xanthomatosis

Note

If the manuscript was presented as part at a meeting, the organization, place, and exact date on which it was read. A full statement to the editor about all submissions and previous reports that might be regarded as redundant publication of the same or very similar work. Any such work should be referred to specifically, and referenced in the new paper.


Authors Contributions

A.K., A.S. and H.S.E. - Data collection and analysis.


A.S. and V.M. - Literature search and review.




Publication History

Article published online:
06 March 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Jung-Woo P. Foam cell formation associated with a borderline ovarian tumor: a case report. Curr Gynecol Oncol 2020; 18 (02) e57
    CrossrefGoogle Scholar
  • 2 Guerrini V, Gennaro ML. Foam cells: one size doesn't fit all. Trends Immunol 2019; 40 (12) 1163-1179
    CrossrefPubMedGoogle Scholar
  • 3 Rakina MA, Kazakova EO, Sudarskikh TS. et al. Giant foam-like macrophages in advanced ovarian cancer. Siberian J Oncol 2022; 21 (02) 45-54
    CrossrefGoogle Scholar
  • 4 Vidhale SA, Chavarkar SP, Sudhamani S, Rao R. Cholesterolosis of ovary associated with benign serous cystadenoma. Indian J Pathol Microbiol 2022; 65 (02) 496-498
    CrossrefPubMedGoogle Scholar
  • 5 Karigoudar MH, Kushtagi AV, Karigoudar RM, Sirasagi A. Xanthogranulomatous oophoritis: a rare inflammatory lesion. J Krishna Inst Med Sci Univ. 2013; 2: 111-115
    Google Scholar
  • 6 Bhatnagar K, Narang V, Garg B, Sood N. Xanthogranulomatous oophoritis: a rare case report. Iran J Pathol 2018; 13 (03) 372-376
    PubMedGoogle Scholar
  • 7 Jones NL, Reagan JW, Willingham MC. The pathogenesis of foam cell formation: modified LDL stimulates uptake of co-incubated LDL via macropinocytosis. Arterioscler Thromb Vasc Biol 2000; 20 (03) 773-781
    CrossrefPubMedGoogle Scholar
  • 8 Köbel M, Kang EY. The evolution of ovarian carcinoma subclassification. Cancers (Basel) 2022; 14 (02) 416
    CrossrefPubMedGoogle Scholar
  • 9 Luo Y, Duan H, Qian Y. et al. Macrophagic CD146 promotes foam cell formation and retention during atherosclerosis. Cell Res 2017; 27 (03) 352-372
    CrossrefPubMedGoogle Scholar
  • 10 Morales C, García-Pardo L, Reymundo C, Bellido C, Sánchez-Criado JE, Gaytán F. Different patterns of structural luteolysis in the human corpus luteum of menstruation. Hum Reprod 2000; 15 (10) 2119-2128
    CrossrefPubMedGoogle Scholar