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Int J Angiol
DOI: 10.1055/s-0044-1785487
Review Article

Epidemiology, Etiology, and Pathophysiology of Pulmonary Embolism

Catherine R. Glazier
1   School of Medicine, University College Dublin, Dublin, Ireland
,
Frank A. Baciewicz Jr.
2   Division of Cardiothoracic Surgery, Wayne State University School of Medicine, Detroit, Michigan
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Abstract

Over the last 20 years, there has been a progressive increase in the incidence of pulmonary embolism (PE) diagnosis in the United States, Europe, and Australia. Increased use of computed tomography pulmonary angiography has likely contributed in part to this rising incidence. However, it is pertinent to note that the burden of comorbidities associated with PE, such as malignancy, obesity, and advanced age, has also increased over the past 20 years. Time-trend analysis in North American, European, and Asian populations suggests that mortality rates associated with PE have been declining. The reported improved survival rates in PE over the past 20 years are likely, at least in part, to be the result of better adherence to guidelines, improved risk stratification, and enhanced treatment. Factors contributing to the development of venous thromboembolism (VTE) include stasis of blood, hypercoagulability, endothelial injury, and inflammation. In 70 to 80% of cases of PE, the thrombi embolizes from the proximal deep veins of the lower extremities and pelvis. Strong risk factors for VTE include lower extremity fractures and surgeries, major trauma, and hospitalization within the previous 3 months for acute myocardial infarction or heart failure with atrial fibrillation. Acute PE causes several pathophysiological responses including hypoxemia and right ventricle (RV) failure. The latter is a result of pulmonary artery occlusion and associated vasoconstriction. Hemodynamic compromise from RV failure is the principal cause of poor outcome in patients with acute PE.

Keywords

pulmonary embolism - thromboembolic disease - venous thrombosis - epidemiology - pathophysiology - etiology - risk factors


Publication History

Article published online:
12 April 2024

© 2024. International College of Angiology. This article is published by Thieme.

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