Subscribe to RSS
DOI: 10.1055/s-0044-1792114
Botulinum Toxin's Effects on Muscle Tone and Joint Mobility in Children with Congenital Zika Syndrome – A Case Series
Article in several languages: português | English Financial Support The authors declare that the did not receive financial support from agencies in the public, private, or non-profit sectors to conduct the present study.
Abstract
Objective To evaluate the effects of the botulinum toxin (BTX-A) on muscle tone and joint mobility in children with congenital Zika syndrome (CZS).
Methods This was a longitudinal case series carried out in a Support Center for Children with Microcephaly, located in Northeastern Brazil. We collected data from the institution's medical records, containing information about muscle tone and passive joint mobility measured at least 3 months before and 4 weeks after BTX-A application.
Results We evaluated 13 children (9 boys) with a mean age of 77 ± 7.1 months. After BTX-A application, a bilateral reduction in the hypertonia level was observed in the elbow flexor (p < 0.01) and hip abductor (p < 0.05) muscles.
Conclusion No changes were observed in joint mobility and no adverse effects were reported by caregivers after application. The use of BTX-A can reduce hypertonia in CZS children, with no impact on joint mobility.
Work carried out at the Professor Joaquim Amorim Neto Research Institute (IPESQ), Campina Grande, PB, Brazil.
Publication History
Received: 30 January 2024
Accepted: 15 August 2024
Article published online:
21 December 2024
© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)
Thieme Revinter Publicações Ltda.
Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil