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CC BY-NC-ND 4.0 · Indian J Radiol Imaging
DOI: 10.1055/s-0044-1796643
Original Article

CECT and CT Perfusion Correlation with Pathological Differentiation of Pharyngeal and Laryngeal Cancers: Study from a Tertiary Care Center in Northeast India

Himraj Phukan
1   Department of Radiology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India
,
Donboklang Lynser
1   Department of Radiology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India
,
Chhunthang Daniala
1   Department of Radiology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India
,
Vandana Raphael
2   Department of Pathology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India
,
Caleb Harris
3   Department of Surgical Oncology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India
,
Suvamoy Chakraborty
4   Department of ENT, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India
› Institutsangaben Funding None.
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Abstract

Introduction Pharyngeal and laryngeal carcinomas, included under head and neck cancers, pose a significant challenge in India, accounting for around one-third of all cancer cases. Noninvasive techniques like contrast-enhanced computed tomography (CECT) and CT perfusion (CTp) can help explore the correlation between tumor differentiations, which can greatly benefit in the diagnosis, understanding of recurrence postintervention, and monitoring of the progress of the disease.

Methods A hospital-based cross-sectional study was conducted for a duration of 18 months in a tertiary care center of northeast India with a sample of 40 patients. CECT and CTp were done and the variables were correlated with pathological differentiation of tumors.

Results The mean age of the study population was 54 years. No statistically significant associations were noted between the age, size, margins, location, and T-staging of tumors with the pathological differentiation of tumors. However, significant association was found between the CTp parameters, namely blood flow (BF), blood volume, mean transit time, time to drain, and time to peak with respect to the pathological differentiation of tumors (p < 0.05).

Conclusion The addition of CTp to conventional CT sequences in the evaluation of pharyngeal and laryngeal cancers offers significant benefits in understanding the tumor physiology and behavior.

Keywords

blood flow - blood volume - computed tomography perfusion - contrast-enhanced computed tomography - mean transit time - pharyngeal and laryngeal cancers - time to drain - time to peak


Publikationsverlauf

Artikel online veröffentlicht:
11. Dezember 2024

© 2024. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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