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CC BY 4.0 · Journal of Health and Allied Sciences NU
DOI: 10.1055/s-0044-1801764
Review Article

Insights from Ayurveda for Diabetes, Oral Health, and Their Interface

Biju Thomas 
1   Department of Periodontics, AB Shetty Memorial Institute of Dental Sciences (ABSMIDS), Mangalore, Karnataka, India
,
Supriya Bhalerao
2   Obesity-Diabetes Laboratory, Interactive Research School for Health Affairs, Pune, Maharashtra, India
,
Maya Indurkar
3   Department of Periodontology, Government Dental College and Hospital, Aurangabad, Maharashtra, India
,
Manas V. Vyas
4   Head Regulatory Affairs, Colgate-Palmolive (India) Ltd., Mumbai, Maharashtra, India
,
Sameer Mahajan
5   MD Ayurveda Medicine, Uranus Health Home and Research Center, Mulund, East Mumbai
,
P. L. Ravishankar
6   Department of Periodontics, SRM Kattankulathur Dental College, Potheri, Tamil Nadu, India
,
Ashish Jain
7   Department of Periodontology, Dr. H. S. J. Institute of Dental Sciences, Punjab University, Chandigarh, India
,
Ashish Kumar
8   Department of Periodontology, Dental College, Regional Institute of Medical Sciences (RIMS), Imphal, Manipur, India
,
Vishakha Grover
7   Department of Periodontology, Dr. H. S. J. Institute of Dental Sciences, Punjab University, Chandigarh, India
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Abstract

Diabetes-related metabolic disturbances have a negative impact on oral health as well. The reciprocal relationship between periodontal health and glycemic management has been already established. Both these pose important concerns to public health, and need to be addressed carefully. Ayurveda, the Indian Traditional Medicine System, has dealt in detail with the pathophysiology and management of prameha (diabetes) as well as various oral diseases including dantamoola vyadhi (periodontal diseases). Interestingly, the causative factors for dantamoola vyadhi are greatly similar to those of prameha. Ayurveda propounds formulations such as triphala, which are reported to possess antihyperglycemic activity as well as antimicrobial activity. Hence, such formulations can prove helpful in the management of both these diseases. Considering the global upsurge in research on traditional medicines worldwide, it is the need of the hour to consider the role of Ayurveda in the oral health issues of diabetic patients. The present review discusses the Ayurvedic concepts of diabetes and periodontal health along with their management.

Keywords

prameha - oral health - dantamoola vyadhi - pyorrhea


Publication History

Article published online:
08 January 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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  • References

  • 1 Genco RJ, Graziani F, Hasturk H. Effects of periodontal disease on glycemic control, complications, and incidence of diabetes mellitus. Periodontol 2000 2020; 83 (01) 59-65
    CrossrefPubMedSearch in Google Scholar
  • 2 Charak Samhita, Nidana Sthana, Prameha Nidan, Chapter 4. Accessed at: https://niimh.nic.in/ebooks/ecaraka/?mod=read
  • 3 Chandran S, Mangalasseri P, Patgiri BJ. et al. Diabetis mellitus in Ayurveda WSR to its aetiopathogenesis. Int J Curr Res 2017; 9: 49173-49177
    Search in Google Scholar
  • 4 Charak Samhita. Chapter 6, Accessed at https://niimh.nic.in/ebooks/ecaraka/?mod=read
  • 5 Mittra S, Bansal VS, Bhatnagar PK. From a glucocentric to a lipocentric approach towards metabolic syndrome. Drug Discov Today 2008; 13 (5–6): 211-218
    CrossrefPubMedSearch in Google Scholar
  • 6 Zheng Y, Ley SH, Hu FB. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol 2018; 14 (02) 88-98
    CrossrefPubMedSearch in Google Scholar
  • 7 Hardy ML, Coulter I, Venuturupalli S. et al. Ayurvedic interventions for diabetes mellitus: a systematic review. Evid Rep Technol Assess (Summ) 2001; 41 (41) 2p
    Search in Google Scholar
  • 8 Unnikrishnan AG, Bhattacharyya A, Baruah MP, Sinha B, Dharmalingam M, Rao PV. Importance of achieving the composite endpoints in diabetes. Indian J Endocrinol Metab 2013; 17 (05) 835-843
    CrossrefPubMedSearch in Google Scholar
  • 9 Einarson TR, Garg M, Kaur V, Hemels ME. Composite endpoints in trials of type-2 diabetes. Diabetes Obes Metab 2014; 16 (06) 492-499
    CrossrefPubMedSearch in Google Scholar
  • 10 Sharma R, Amin H, Ruknuddin G, Prajapati PK. Efficacy of ayurvedic remedies in type 2 diabetes: a review through works done at Gujarat Ayurved University, Jamnagar. J Med Nutr Nutraceut 2015; 4: 63-69
    CrossrefSearch in Google Scholar
  • 11 Khandelwal N, Dhundi SN, Yadav P, Prajapati PK. Prevention and management of diabetes mellitus in Ayurveda. Asian J Biomed Pharmaceut Sci 2011; 1: 1-6
    Search in Google Scholar
  • 12 Srikanth N, Haripriya N, Singh R, , Manjula, Tewari D. Diabetes mellitus (Madhumeha) and ayurvedic management: an evidence based approach. World J Pharm Pharm Sci 2015; 4: 881-892
    Search in Google Scholar
  • 13 Charak Samhita, Chikitsa Sthana, Trishna Chikitsa. Chapter 22. Accessed at https://niimh.nic.in/ebooks/ecaraka/?mod=read
  • 14 Sen G. Siddhantanidanam: A Textbook of Etiology, Pathology, Symptomatology (Part I and II). Translated by Srikanthamurthy KR. Varanasi: Chaukhamba Sanskrit Series Office; 1924
    Search in Google Scholar
  • 15 Gond P, Singh L. Concept of infected wound (DushtaVrana) in ayurveda. J Adv Res Ayur Yoga Unani Sidd Homeo 2017; 4: 11-15
    Search in Google Scholar
  • 16 Egede LE, Ye X, Zheng D, Silverstein MD. The prevalence and pattern of complementary and alternative medicine use in individuals with diabetes. Diabetes Care 2002; 25 (02) 324-329
    CrossrefPubMedSearch in Google Scholar
  • 17 Gordon A, Buch Z, Baute V, Coeytaux R. Use of ayurveda in the treatment of type 2 diabetes mellitus. Glob Adv Health Med 2019; 8: 2164956119861094
    CrossrefPubMedSearch in Google Scholar
  • 18 Chauhan A, Semwal RB, Semwal DK. Ayurvedic approaches used in prevention and treatment of type 2 diabetes mellitus. J Convent Knowl Holist Health 2017; 1: 1-15
    CrossrefSearch in Google Scholar
  • 19 Khan F, Sarker MMR, Ming LC. et al. Comprehensive review on phytochemicals, pharmacological and clinical potentials of Gymnema sylvestre . Front Pharmacol 2019; 10: 1223
    CrossrefPubMedSearch in Google Scholar
  • 20 Radha MH, Laxmipriya NP. Evaluation of biological properties and clinical effectiveness of Aloe vera: a systematic review. J Tradit Complement Med 2014; 5 (01) 21-26
    CrossrefPubMedSearch in Google Scholar
  • 21 Peter EL, Kasali FM, Deyno S. et al. Momordica charantia L. lowers elevated glycaemia in type 2 diabetes mellitus patients: systematic review and meta-analysis. J Ethnopharmacol 2019; 231: 311-324
    CrossrefPubMedSearch in Google Scholar
  • 22 Ahmad A, Husain A, Mujeeb M. et al. A review on therapeutic potential of Nigella sativa: a miracle herb. Asian Pac J Trop Biomed 2013; 3 (05) 337-352
    CrossrefPubMedSearch in Google Scholar
  • 23 Liang Y, Xu X, Yin M. et al. Effects of berberine on blood glucose in patients with type 2 diabetes mellitus: a systematic literature review and a meta-analysis. Endocr J 2019; 66 (01) 51-63
    CrossrefPubMedSearch in Google Scholar
  • 24 Gupta BP, Sharma I, Kohli N, Sharma S, Rathi A, Sharma AK. Preliminary clinical assessment and non- toxicity evaluation of an ayurvedic formulation BGR-34 in NIDDM. J Tradit Complement Med 2018; 8 (04) 506-514
    CrossrefPubMedSearch in Google Scholar
  • 25 Setia M, Meena K, Madaan A, Srikanth N, Dhiman KS, Sastry JLN. In vitro studies on antidiabetic potential of new dosage forms of AYUSH 82. J Drug Res Ayurvedic Sci 2017; 2: 1-9
    CrossrefSearch in Google Scholar
  • 26 Panda AK, Ratha KK, Rao MM. Efficacy of ayurveda formulation Ayush-82 (IME-9) in newly diagnosed type 2 diabetics: retrospective analysis of individual data. J Tradit Med Clin Naturop 2017; 6: 250
    Search in Google Scholar
  • 27 Pandey RK, Bhatt NN, Singhala TM, Shukla VD. A comparative study of Vamana and Virechana Karma in the management of Sthula Pramehi w.s.r. to Type-2 diabetes. Ayu 2011; 32 (04) 536-539
    CrossrefPubMedSearch in Google Scholar
  • 28 Chen TS, Liou SY, Wu HC. et al. Efficacy of epigallocatechin-3-gallate and Amla (Emblica officinalis) extract for the treatment of diabetic-uremic patients. J Med Food 2011; 14 (7–8): 718-723
    CrossrefPubMedSearch in Google Scholar
  • 29 Pivari F, Mingione A, Brasacchio C, Soldati L. Curcumin and type 2 diabetes mellitus: prevention and treatment. Nutrients 2019; 11 (08) 1837
    CrossrefPubMedSearch in Google Scholar
  • 30 Vora A, Varghese A, Kachwala Y. et al. Eugenia jambolana extract reduces the systemic exposure of Sitagliptin and improves conditions associated with diabetes: a pharmacokinetic and a pharmacodynamic herb-drug interaction study. J Tradit Complement Med 2018; 9 (04) 364-371
    CrossrefPubMedSearch in Google Scholar
  • 31 Geberemeskel GA, Debebe YG, Nguse NA. Antidiabetic effect of Fenugreek seed powder solution (Trigonella foenum- graecum L.) on hyperlipidemia in diabetic patients. J Diabetes Res 2019; 2019: 8507453
    CrossrefPubMedSearch in Google Scholar
  • 32 Najdi RA, Hagras MM, Kamel FO, Magadmi RM. A randomized controlled clinical trial evaluating the effect of Trigonella foenum-graecum (fenugreek) versus glibenclamide in patients with diabetes. Afr Health Sci 2019; 19 (01) 1594-1601
    CrossrefPubMedSearch in Google Scholar
  • 33 Waheed A, Miana GA, Ahmad SI. Clinical investigation of hypoglycemic effect of seeds of Azadirachta-inidca in type-2 (NIDDM) diabetes mellitus. Pak J Pharm Sci 2006; 19 (04) 322-325
    PubMedSearch in Google Scholar
  • 34 Nakanekar A, Kohli K, Tatke P. Ayurvedic polyherbal combination (PDBT) for prediabetes: a randomized double blind placebo controlled study. J Ayurveda Integr Med 2019; 10 (04) 284-289
    CrossrefPubMedSearch in Google Scholar
  • 35 Amruthesh S. Dentistry and Ayurveda - IV: classification and management of common oral diseases. Indian J Dent Res 2008; 19 (01) 52-61
    CrossrefPubMedSearch in Google Scholar
  • 36 Ashtanga Hridaya Uttarasthana. Chapter 21, Mukharoga vigyaniya, Verse 1–2. Accessed December 22, 2024 at: https://vedotpatti.in/samhita/Vag/ehrudayam/?mod=read
  • 37 Ayurvedic Medicine: In Depth, National Center for Complementary and Integrative Health. https://www.nccih.nih.gov/health/ayurvedic-medicine-in-depth
  • 38 Singh A, Purohit B. Tooth brushing, oil pulling and tissue regeneration: A review of holistic approaches to oral health. J Ayurveda Integr Med 2011; 2 (02) 64-68
    CrossrefPubMedSearch in Google Scholar
  • 39 Al lafi T, Ababneh H. The effect of the extract of the miswak (chewing sticks) used in Jordan and the Middle East on oral bacteria. Int Dent J 1995; 45 (03) 218-222
    PubMedSearch in Google Scholar
  • 40 Maurya DK, Mittal N, Sharma KR, Nath G. Role of triphala in the management of peridontal disease. Anc Sci Life 1997; 17 (02) 120-127
    PubMedSearch in Google Scholar
  • 41 Akhtar MS, Ajmal M. Significance of chewing-sticks (miswaks) in oral hygiene from a pharmacological view-point. J Pak Med Assoc 1981; 31 (04) 89-95
    PubMedSearch in Google Scholar
  • 42 Sharma H, Chandola HM. Prameha in Ayurveda: correlation with obesity, metabolic syndrome, and diabetes mellitus. Part 1-etiology, classification, and pathogenesis. J Altern Complement Med 2011; 17 (06) 491-496
    CrossrefPubMedSearch in Google Scholar