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Synlett 1990; 1990(2): 105-107
DOI: 10.1055/s-1990-21002
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Selective Enzymatic Removal of Protecting Functions: Heptyl Esters as Carboxy Protecting Groups in Peptide Synthesis

Peter Braun* , Herbert Waldmann, Walter Vogt, Horst Kunz
  • *Institut für Organische Chemie, Universität Mainz, Becherweg 18-20, D-6500 Mainz, Federal Republic of Germany
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Publication Date:
08 March 2002 (online)

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From benzyloxycarbonyl (Z), tert-butoxycarbonyl (Boc) and allyloxycarbonyl (Aloc) protected dipeptide heptyl esters the N-terminal protecting groups can be removed by chemical methods and the C-terminal COOH function is liberated selectively by enzymatic hydrolysis with a lipase from Rhizopus niveus.