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Synlett 1991; 1991(3): 153-154
DOI: 10.1055/s-1991-20659
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Preparation of γ-Alkoxy-α-keto Esters by the Lewis Acid Promoted Reaction of 2-(Trimethyl-siloxy)acrylate Esters with Acetals

Hideyuki Sugimura* , Yuji Shigekawa, Minako Uematsu
  • *The Noguchi Institute, 1-8-1, Kaga, Itabashi-ku, Tokyo 173, Japan
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Publication Date:
07 March 2002 (online)

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The reaction of 2-(trimethylsiloxy)acrylate esters, prepared by the silylation of pyruvate esters, with acetals proceeded in the presence of diethyl ether-boron trifluoride complex to afford γ-alkoxy-α-keto esters (alkyl 4-alkoxy-2-oxoalkanoates) in good yield.