PDF herunterladen
Synlett 1991; 1991(6): 405-406
DOI: 10.1055/s-1991-20743
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Facile Synthesis of Methyl 7-Methoxy-2-naphthoate. An Improved Procedure for Monomethylation of 2,7-Naphthalenediol

Philippe Prince* , Richard D. Gandour
  • *Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803-1804, USA
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
07. März 2002 (online)

  als PDF herunterladen  Lizenzen und Reprints Alle Artikel dieser Rubrik

Methyl 7-methoxy-2-naphthoate (1) is prepared in three steps from readily available 2,7-naphthalenediol (2) with an overall yield of 61%. The first step is the monomethylation of 2 by dimethyl sulfate with sodium hydroxide in a two-solvent system (CH2Cl2/H2O), which represents an improvement over past methods. 7-Methoxy-2-naphthol (3) reacts with trifluoromethanesulfonic anhydride (triflic anhydride) to give the corresponding triflate. Palladium-catalyzed methoxycarbonylation of the triflate yields 1.