Synlett 1991; 1991(7): 520-522
DOI: 10.1055/s-1991-20786
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A Stereocontrolled Synthesis of a Key Intermediate to (+)-Thienamycin

Sung Ho Kang* , Wan Joo Kim
  • *Department of Chemistry, Korea Advanced Institute of Science and Technology, Taejon 305-701, South Korea
Further Information

Publication History

Publication Date:
07 March 2002 (online)

A formal synthesis of (+)-thienamycin was achieved by the enantioselective preparation of key intermediate azetidinone 2 [benzyl (2R,3S)-3-{(S)-1-hydroxyethyl}-4-oxo-2-azetidineacetate] via an intramolecular nitrone 1,3-dipolar cycloaddition.