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Synlett 1991; 1991(7): 523-525
DOI: 10.1055/s-1991-20787
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Development of a New Strategy for the Preparation of a C7-C17 Model System of Avermectins and Milbemycins

Yves Langlois* , Nguyen Van Bac
  • *Laboratoire de Synthèse des Substances Naturelles, U.A. CNRS 478, I.C.M.O., Université Paris-Sud, Bâtiment 410, F-91405 Orsay Cedex, France
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Publikationsdatum:
07. März 2002 (online)

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A double Hofmann elimination of a bis(tetrahydropyridinium) salt, prepared from simple pyridine derivatives in six steps, afforded stereoselectively a tetraene [(2E,4E,8Z)-2,8-bis(dimethylaminomethyl)-2,4,8,10-undecatetraen-1-ol], which was further transformed in six steps into a C7-C17 model system of avermectins and milbemycins.