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Synlett 1991; 1991(9): 621-624
DOI: 10.1055/s-1991-20817
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Regioselective Formation of C-Centered Radicals Using the Intramolecular 1,5-Hydrogen Atom Transfer

Daniella Denenmark* , Pascale Hoffmann, Tammo Winkler, Adrian Waldner, Alain De Mesmaeker
  • *Central Research Laboratories, Ciba-Geigy Ltd., CH-4002 Basel, Switzerland
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Publication Date:
07 March 2002 (online)

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A regioselective method for the formation of C-centered radicals using an intramolecular 1,5-hydrogen atom transfer from a C(sp3)-H bond to an aryl radical is described. The efficiency of the process depends on conformational effects rather than on the stabilization of the final radical by the adjacent substituents.