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Synlett 1991; 1991(11): 777-778
DOI: 10.1055/s-1991-20870
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Palladium-Catalyzed Polycyclizations of Enediynes: A Convenient One-Step Synthesis of Polyfunctional Angularly Bisanellated Benzene Derivatives1

Frank E. Meyer* , Armin de Meijere
  • *Institut für Organishe Chemie, Georg-August-Universität Göttingen, Tammannstrasse 2, D-3400 Göttingen, Germany
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Publication Date:
07 March 2002 (online)

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Variously substituted 2-bromotetradec-1-ene-6,12-diynes 9a-d, 10-oxa derivative 5, and 4-oxa derivatives 7a,b cleanly cyclize to highly substituted, bisanellated benzene derivatives 10a-d (2,3,6,7,8,9-hexahydro-1H-benz[e]indenes), 6, and 8a,b (1,2,4,7,8,9-hexahydrocyclopenta[f][2]benzopyrans) under palladium catalysis using Heck-type reaction conditions.