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Synlett 1991; 1991(11): 783-784
DOI: 10.1055/s-1991-20873
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Synthesis of Novel Four-Membered Ring Amino Acids as Modulators of the N-Methyl-D-Aspartate(NMDA) Receptor Complex

Alan P. Kozikowski* , Abdul H. Fauq
  • *Neurochemistry Research, 4500 San Pablo Road, Mayo Clinic Jacksonville, Jacksonville, Florida 32224, USA
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Publication Date:
07 March 2002 (online)

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The first syntheses of three novel four-membered ring amino acids (3-aminooxetane-3-carboxylic acid, 3-aminoazetidine-3-carboxylic acid and 3-aminothietane-3-carboxylic acid), starting from 1-chloro-2,3-epoxypropane, are reported together with a summary of their biological actions at the NMDA receptor-ion channel complex.