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Synlett 1991; 1991(11): 803-804
DOI: 10.1055/s-1991-20882
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Preparation of tert-Butyl 4-N-(ω-Aminoalkyl)aminobenzoates by Nucleophilic Aromatic Substitution

S. Barret Kalindjian* , Richard A. G. Smith
  • *SmithKline Beecham Pharmaceuticals, Great Burgh, Yew Tree Bottom Road, Epsom, Surrey KT18 5XQ, England
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Publikationsdatum:
07. März 2002 (online)

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Nucleophilic aromatic substitution of tert-butyl 4-fluorobenzoate (3) with α,ω-diamines 5 has been used to provide the synthetic intermediates 2 [tert-butyl 4-N-(ω-aminoalkyl)amino-benzoates] in good yields.