RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000083.xml
Synlett 1991; 1991(5): 343-344
DOI: 10.1055/s-1991-34738
DOI: 10.1055/s-1991-34738
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.
Formal Total Synthesis of Clausenamide
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
07. März 2002 (online)
Ruthenium tetroxide oxidation of trans-5-substituted 4-acylaminocyclohexenes 2 followed by esterification gave N-protected cis-4-substituted 5-(methoxycarbonylmethyl)-2-pyrrolidones 4. The resulting pyrrolidone 4a (N-Boc-4-phenyl) was converted into the key intermediate 8 (cis-5-formal-1-methyl-4-phenyl-2-pyrrolidinone), thus achieving the formal total synthesis of clausenamide [3-hydroxy-5-(α-hydroxybenzyl)-1-methyl-4-phenyl-2-pyrrolidinone].