PDF herunterladen
Synlett 1991; 1991(10): 753-754
DOI: 10.1055/s-1991-34774
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Enzymatic Synthesis of 2′,3′-Dideoxyguanosine

Vasu Nair* , Todd B. Sells
  • *Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
13. März 2002 (online)

  als PDF herunterladen  Lizenzen und Reprints Alle Artikel dieser Rubrik

2′,3′-Dideoxyguanosine (ddG) can be conveniently synthesized in very high yields by utilizing the hydrolase activity of the ubiquitous mammalian enzyme, adenosine deaminase (ADA). The immediate precursor in this synthesis is 2-amino-6-chloro-2′,3′-dideoxypurine nucleoside, which is readily prepared from guanosine.