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Synlett 1992; 1992(1): 51-52
DOI: 10.1055/s-1992-21262
DOI: 10.1055/s-1992-21262
letter
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The Total Synthesis of (+)-Palitantin
Further Information
Publication History
Publication Date:
18 September 2002 (online)
![](https://www.thieme-connect.de/media/synlett/199201/lookinside/thumbnails/10.1055-s-1992-21262-1.jpg)
An asymmetric synthesis of (+)-palitantin [1;(2R,3R,5S,6R)-5-(1,3-heptadienyl) -2,3-dihydroxy-6-hydroxymethyl-cyclohexanone] is described, starting from the homochiral alcohol (-)-3 [(1S,2S,3R) -2,3-isopropylidenedioxycyclohexanol], obtained via lipase-mediated resolution. Key steps include a regioselective dehydration and stereoselective cuprate addition.