Download PDF
Synlett 1992; 1992(3): 179-188
DOI: 10.1055/s-1992-21307
account
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

C-5-Substituted Nucleoside Analogs

Don Bergstrom* , Xiaoping Lin, Guangyi Wang, David Rotstein, Peter Beal, Kathryn Norrix, Jerry Ruth
  • *Department of Medicinal Chemistry and Pharmacognosy, Purdue University, West Lafayette, Indiana 47907, USA
Further Information

Publication History

Publication Date:
08 March 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

Nucleosides modified at C-5 of the pyrimidine base have become important components of synthetic oligonucleotide probes. An account of how these compounds can be synthesized by way of palladium-mediated reactions is described. 1. Introduction 2. Palladium-Mediated Reactions of Alkenes with Mercurionucleosides 3. C-5 Substituted Nucleosides as Antiviral Agents 4. DNA Probes from Modified Nucleosides 5. Palladium-Mediated Reaction of Disulfides with Mercurionucleosides 6. Conclusion