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Synlett 1993; 1993(2): 137-138
DOI: 10.1055/s-1993-22378
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A Short Diastereoselective Synthesis of 2,3-Disubstituted Succinates

R. Paul Beckett* , Michael J. Crimmin, Mark H. Davis, Zoé Spavold
  • *Medicinal Chemistry Dept., British Bio-technology Ltd., Brook House, Watlington Rd., Cowley, Oxford, OX4 5LY, England
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Publication History

Publication Date:
19 March 2002 (online)

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Alkylation of optically active succinic acid half esters provides a stereoselective route to 2,3 disubstituted succinates. Enolate formation and quenching leads to selective inversion of the stereochemistry at the newly alkylated centre.