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Synlett 1993; 1993(2): 148
DOI: 10.1055/s-1993-22383
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A Convenient Synthesis of α-Ketodithioesters from Methylketones

Didier Villemin* , Frédéric Thibault-Starzyk
  • *Institut des Sciences de la Matière et du Rayonnement, URA CNRS 0480, 6 Boulevard du Maréchal Juin, F-14050 Caen, France
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Publication Date:
19 March 2002 (online)

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Methylketones (1) react with iodine and pyridine to give ketopyridinium iodides (2). In the presence of triethylamine and sulfur, these salts lead to α-ketodithiocarboxylates which can be alkylated with iodomethane into methyl α-ketodithioesters (3). This sequence constitutes a convenient synthesis of α-ketodithioesters from methylketones.