Download PDF
Synlett 1993; 1993(4): 273-274
DOI: 10.1055/s-1993-22428
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A Novel Efficient Synthesis of 1-Ethoxyvinyl Esters and Their Use in Acylation of Amines and Alcohols: Synthesis of Water-Soluble Oxaunomycin Derivatives

Yasuyuki Kita* , Hiroshi Maeda, Kana Omori, Takayuki Okuno, Yasumitsu Tamura
  • *Faculty of Pharmaceutical Sciences, Osaka University, 1-6, Yamada-oka, Suita, Osaka 565, Japan
Further Information

Publication History

Publication Date:
19 March 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

1-Ethoxyvinyl esters (1a-i), prepared by the addition of carboxylic acids to ethoxyacetylene in the presence of a catalytic amount of [RuCl2(p-cymene)]2, react with amines (3a-d) and alcohols (5a-e) to give the corresponding N- and O-acylated compounds (4a-l and 6a-f) in high yields. Application of this method to the synthesis of water-soluble oxaunomycin derivatives (9a,b) is also described.