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Synlett 1993; 1993(6): 389-390
DOI: 10.1055/s-1993-22464
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A Facile Synthetic Method for Pyrimidine Acylclonucleoside Analogues from Alkoxy-1,4-Diheterocycloheptanes

M. A. Gallo* , A. Espinosa, J. Campos, A. Entrena, J. F. Domínguez, E. Camacho, M. J. Pineda, J. A. Gómez
  • *Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Granada, 18071 Granada, Spain
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Publikationsdatum:
19. März 2002 (online)

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Twenty four pyrimidine (5-fluoro-, 5-iodo-, 5-trifluoromethyl-uracil, uracil itself and thymine) acyclic nucleoside analogues in which the group attached at N-1 is an alkyl opened chain with two heteroatoms, 3-(2-hydroxyethylhetero)-1-alkoxy-1 [1-(5-substituted-uracil)]-propane, have been synthesized with fairly good yields. A possible intermediate is proposed on the basis of the regiospecificity of the reaction.