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Synlett 1993; 1993(7): 506
DOI: 10.1055/s-1993-22508
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Microwave-Mediated Synthesis of Amides

M. Pilar Vázquez-Tato*
  • *Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Santiago, Campus de Lugo, Aptdo. 280, E-27080 Lugo, Spain
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Publikationsdatum:
19. März 2002 (online)

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Microwave irradiation provides a fast, simple method for the preparation of amides from aliphatic amines and carboxylic acids.

Microwave irradiation has become a very useful tool in organic synthesis.1 It has been used to enhance a great number of classical organic reactions, including Diels-Alder reactions and hydrolysis. Though it, sometimes requires special equipment such as Teflon reactors or specially designed microwave ovens it can be applied to some reactions using just beakers or test tubes as reaction vessels and an ordinary domestic microwave oven. This article describes the use of microwaves as the source of heat for the synthesis of amides by pyrolysis of the salt of the amine and the carboxylic acid. To my knowledge, there has been no previous study of this application of microwave ovens.