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Synlett 1993; 1993(10): 764-766
DOI: 10.1055/s-1993-22601
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Reaction of Aziridines with Dianions Derived from ß-Ketoesters: Application to the Preparation of Substituted Pyrrolidines

Barry Lygo*
  • *Department of Chemistry and Applied Chemistry, University of Salford, Manchester, M5 4WT, England
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Publikationsdatum:
19. März 2002 (online)

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The nucleophilic ring opening of N-tosyl aziridines using the dianions derived from ß-ketoesters has been studied. Acid-mediated cyclisation of the resulting amino ß-ketoesters to a number of substituted pyrrolidines has also been examined.