Acyclic Diastereofacial Selection in Intermolecular Radical Reactions Steric vs Electronic Controls

Starting from chiral acyclic substrates, stereoselective intermolecular radical reactions leading to 1,2 and 1,4-asymmetric inductions are described. The synthetic usefulness of these reactions occuring through radical processes being demonstrated, a rationalization of the 1,2-asymmetric induction is attempted in terms of steric vs electronic controls . 1 Introduction 2 Relative 1,2-Asymmetric Inductions (Substrate Control). 2.1 α-Chiral Radicals A (Tables I to IV). 2.2 α-Chiral Olefins B ((Table V). 3 Relative 1,4-Asymmetric Inductions (Chiral Auxiliary Control) 3.1 δ-Chiral Radicals C (Table VI) 3.2 δ-Chiral Olefins D) (Table VII) 4 Conclusion