Download PDF
Synlett 1994; 1994(3): 199-200
DOI: 10.1055/s-1994-22793
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Enantioselective Synthesis of 1,3-Dioxygen-substituted Chiral Building Blocks

Chris H. Senanayake* , Robert D. Larsen, Timothy J. Bill, Ji Liu, Edward G. Corley, Paul J. Reider
  • *Department of Process Research, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, USA
Further Information

Publication History

Publication Date:
22 March 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

The extremely useful chiral building blocks 3-hydroxy-2-alkylpropionates 8 are prepared in either S or R eantiomeric form via the diastereoselective addition of chiral alcohols to arylketenes 4 and the manipulation of the resultant chiral 2-arylaliphatic esters 5 and 6. Application of this methodology to the asymmetric syntheses of 3-mercapto-2-alkylpropionates (9) and (S)-(-)-paraconic acid (3) is described.