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Synlett 1994; 1994(4): 275-276
DOI: 10.1055/s-1994-22826
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Asymmetric Synthesis of Functionalized Tertiary Alcohols by Diastereoselective Aldol Reaction of Silyl Enol Ether and Ketene Silyl Acetal with α-Keto Esters Bearing an Optically Active Cyclitol as a Chiral Auxiliary

Takahiko AKIYAMA* , Keiichiro ISHIKAWA, Shoichiro OZAKI
  • *Department of Applied Chemistry, Faculty of Engineering, Ehime University, Bunkyo-cho, Matsuyama 790, Japan
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Publication Date:
22 March 2002 (online)

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Tin (IV) chloride promoted aldol reactions of silyl enol ether and ketene silyl acetal with α-keto esters derived from L-quebrachitol afforded the corresponding aldol-type adduct, α-hydroxy acid derivatives, in good yields with excellent diastereomeric excesses.