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Synlett 1994; 1994(9): 702-704
DOI: 10.1055/s-1994-22977
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Total Synthesis of Thiangazole

Juerg Ehrler* , Saleem Farooq
  • *Ciba Crop Protection, Ciba-Geigy Ltd., CH-4002 Basle, Switzerland
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Publikationsdatum:
18. September 2002 (online)

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The total synthesis of thiangazole (1), a tris-thiazoline- oxazole metabolite isolated from Polyangium spec., strain PI 3007, is described utilizing the stepwise formation of the thiazoline moieties with ethyl (R)-2-methyl-cysteine which is obtained by preparative HPLC-separation of the racemic 2-phenylthiazoline derivative 8 followed by acidic hydrolysis.