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Synlett 1994; 1994(11): 925-928
DOI: 10.1055/s-1994-23050
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Enantioselective Synthesis of Novel Functionalised Prolines via [3 + 2] Cycloadditions of a Chiral Azomethine Ylid

Jack E. Baldwin* , Sean C. MacKenzie Turner, Mark G. Moloney
  • *Dyson Perrins Laboratory, South Parks Road, University of Oxford, Oxford OX1 3QY, UK
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Publication Date:
22 March 2002 (online)

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The chiral, stabilised azomethine ylid 2 derived from (S)-2-phenylglycinol underwent enantioselective [3 + 2] cycloaddition reactions with a variety of unactivated and monoactivated dipolarophiles. Cycloaddition products were successfully deprotected to give chiral, functionalised proline derivatives.