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Synthesis 1994; 1994(12): 1403-1405
DOI: 10.1055/s-1994-25700
DOI: 10.1055/s-1994-25700
short paper
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An Efficient Route to α,β-Epoxy Ketones of High Enantiomerical Purity
Further Information
Publication History
Publication Date:
25 April 2002 (online)
Acylepoxides were obtained in high enantiomeric purity (ee = 92-99%) by addition of organolithium or Grignard reagents to enantiomerically pure methyl or ethyl 2,3-epoxypropanoates at low temperature ( - 85°C)