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Synlett 1995; 1995(2): 213
DOI: 10.1055/s-1995-4918
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Two Practical Syntheses of a Key Intermediate of 1β-Methylcarbapenem Antibiotics

Hikaru Itani, Shoichiro Uyeo*
  • *Shionogi Research Laboratories, Shionogi & Co., Ltd., Sagisu, Fukushima-ku, Osaka 553, Japan
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Publication Date:
31 December 2000 (online)

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Two practical methods for the synthesis of a key intermediate 1 of 1β-methylcarbapenem antibiotics, starting from 4 via readily available olefins 5 and 7, respectively, are described.

1β-methylcarbapenem key Intermediate - azetidinone carboxylic acid - stereoselective synthesis - potassium permanganate oxidation