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Synlett 1995; 1995(8): 817-818
DOI: 10.1055/s-1995-5086
DOI: 10.1055/s-1995-5086
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An Efficient Synthesis of the Methyl Ester of Benzoleukotriene B3, a Leukotriene B4 Analogue
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Publication History
Publication Date:
31 December 2000 (online)
The synthesis of benzoleukotriene B3 methyl ester has been easily achieved by a palladium-catalyzed dienylstannane/aryl halide coupling reaction. A selective and sequential electrophilic substitution with acyl chlorides, followed by a reduction reaction, leads to the title compound.
Benzoleukotriene B3 - cross-coupling reaction - electrophilic substitution