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Synlett 1995; 1995(8): 853-854
DOI: 10.1055/s-1995-5093
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Tetrabutylammonium Dihydrogentrifluoride as a Powerful Catalyst in the Regioselective Opening of Epoxides with Activated Aromatic and Heteroaromatic Chlorides

D. Albanese, D. Landini, A. Maia, M. Penso*
  • *Centro CNR and Dipartimento di Chimica Organica e Industriale dell’Università, Via Golgi 19, I-20133 Milano, Italy, Fax +2 236 4369; research%iumchz@imiclvx.bitnet
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Publication History

Publication Date:
31 December 2000 (online)

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Tetrabutylammonium dihydrogentrifluoride, Bu4N+H2F3-, was found to be a very efficient catalyst in the ring opening of epoxides by aromatic or heteroaromatic chlorides to prepare the corresponding 2-aryloxy- or 2-heteroaryloxy-1-chloroalkyl derivatives 8 in 62-87% yield, by operating at 90 °C without solvent.

Tetrabutylammonium Dihydrogentrifluoride - Epoxides - Ring Opening - Regioselective - Aromatic Chlorides