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Synlett 1995; 1995(10): 1017-1020
DOI: 10.1055/s-1995-5164
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Solid Phase Synthesis of Bicyclo[2.2.2]octane Derivatives via Tandem Michael Addition Reactions and Subsequent Reductive Amination

Steven V. Ley* , Donna M. Mynett, Wim-Jan Koot
  • *Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
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Publikationsdatum:
31. Dezember 2000 (online)

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Tandem Michael addition reactions of polymer bound acrylates with cyclohexenones and subsequent reductive amination was achieved, which after cleavage from the support under reductive, acidolytic or aminolytic conditions afforded a wide variety of bicyclo[2.2.2]octanes. The process may find application in combinatorial library synthesis.

Solid Phase Synthesis - Tandem Michael Addition - Reductive Amination