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Synlett 1995; 1995(SI): 519-522
DOI: 10.1055/s-1995-5273
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Regioselective Olefin Hydroformylation as a Route to Indolizidine and Pyrrolizidine Alkaloids

G. D. Cuny, S. L. Buchwald*
  • *Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139
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Publication Date:
31 December 2000 (online)

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Regioselective, rhodium-catalyzed hydroformylation of olefinic pyrrolidine derivatives was utilized as a key step in the formal syntheses of the indolizidine alkaloids (±)-167B, 2, and (±)-209D, 3, and the ant venom pyrrolizidine alkaloid (3S,5R,8S)-3-heptyl-5-methylpyrrolizidine, 4.

hydroformylation - rhodium - indolizidine - pyrrolizidine - alkaloid