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Synlett 1996; 1996(3): 275-277
DOI: 10.1055/s-1996-5375
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Nucleophilic Opening of Epoxide by Guanidine. A Route to Potential Substrates or Inhibitors of NO Synthases1

Christine Gravier-Pelletier, Didier Bourissou, Yves Le Merrer* , Jean-Claude Depezay
  • *Université René Descartes, Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, associé au CNRS, 45, rue des Saints-Pères, 75270 Paris Cedex 06, France
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Publication Date:
31 December 2000 (online)

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An efficient method for the synthesis of monosubstituted guanidines has been developed through the regiospecific nucleophilic opening of an epoxide by free guanidine followed by in situ selective N,N’-bis-benzyloxycarbonyl protection of the guanidine moiety.

Guanidine - bis-epoxide - NO synthases - O-heterocyclisation