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Synlett 1996; 1996(3): 225-226
DOI: 10.1055/s-1996-5388
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Efficient Synthesis of α-Chloro Ketones via Reaction of Organometallic Reagents with N-Methoxy-N-Methylchloroacetamide

R. Tillyer* , L. F. Frey1 , D. M. Tschaen, U.-H. Dolling
  • *Department of Process Research, Merck Research Laboratories, Rahway NJ, USA 07065
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Publication Date:
31 December 2000 (online)

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A simple, high yielding synthesis of α-chloro ketones is described, involving acylation of Grignard and organolithium reagents with N-methoxy-N-methylchloroacetamide. The efficiency of the process is further enhanced by recycling N,O-dimethylhydroxylamine.

Acylation - N,O-dimethylhydroxylamine - Grignard Reagent - α-Chloro Ketone