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Synlett 1996; 1996(5): 449-451
DOI: 10.1055/s-1996-5455
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Biocatalysis in Organic Synthesis 7. Enantioselective Transesterification Catalyzed by an Acylase: Remarkable Influence of Remote Substitution and the Nature of the Solvent on the Selectivity1

Marta Ors, Anabel Morcuende, M. Isabel Jiménez-Vacas, Serafín Valverde, Bernardo Herradón*
  • *Instituto de Química Orgánica General, C.S.I.C., c/ Juan de la Cierva 3, 28006 Madrid, Spain
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Publication History

Publication Date:
31 December 2000 (online)

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Acylase I from Aspergillus species catalyzes the reaction of transesterification between vinyl acetate and racemic derivatives of 2-(hydroxymethyl)piperidine. It has been found that the enantioselectivity of the reaction depends on the solvent. Also it has been observed that remote substituents have a great influence on the enantioselectivity.

Acylase - enantioselective transesterification - amino alcohol - substituent effect - solvent effect