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Synlett 1996; 1996(6): 521-522
DOI: 10.1055/s-1996-5474
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An Improved One-pot Procedure for the Synthesis of Alkynes from Aldehydes

Stephan Müller, Bernd Liepold, Gerald J. Roth, Hans Jürgen Bestmann*
  • *Institut für Organische Chemie der Universität Erlangen-Nürnberg, Henkestraße 42, D-91054 Erlangen, Germany
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Publikationsdatum:
31. Dezember 2000 (online)

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The transformation of aldehydes to terminal alkynes can be achieved with the reagent dimethyl-1-diazo-2-oxopropylphosphonate 2. The one-pot procedure allows the isolation of the products under very mild conditions in good to excellent yields without requiring low temperatures or inert gas techniques and avoiding the use of strong bases.

aldehydes - alkynes - dimethyl-1-diazo-2-oxopropylphosphonate