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Synlett 1996; 1996(6): 568-570
DOI: 10.1055/s-1996-5479
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Synthesis of Substituted Quinolines and Coumarins through a Sequential Vinylic Substitution/Annulation Process

Antonio Arcadi, Sandro Cacchi* , Giancarlo Fabrizi, Fabio Marinelli, Paola Pace
  • *Dipartimento di Studi di Chimica e Tecnologica delle Sostanze Biologicamente Attive, Università ”La Sapienza”, P.le A. Moro 5, 00185 Roma, Italy
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Publication History

Publication Date:
31 December 2000 (online)

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The reaction of unsaturated halides and triflates with readily available 4-(o-acetamidophenyl)-3-buten-2-one and methyl 4-(o-hydroxyphenyl)-3-propenoate in the presence of KOAc and Pd(OAc)2, without phosphine ligands, affords substituted quinolines and coumarins through an in situ vinylic substitution/annulation sequence.

Quinolines - Coumarins - Palladium Catalysis - Vinylic Substitution - Annulation