PDF herunterladen
Synlett 1996; 1996(7): 687-689
DOI: 10.1055/s-1996-5570
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Conformationally Constrained DNA Mimics: Synthesis of a Novel Cyclopropyl-Amide Linked Dimer

Becky Haly, Ramesh Bharadwaj, Yogesh S. Sanghvi*
  • *Medicinal Chemistry Department, Isis Pharmaceuticals, 2292 Faraday Avenue, Carlsbad, CA 92008, U.S.A., Phone: 619-603 2351, Fax: 619-929 0036, e-mail: ysanghvi@isisph.com
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
31. Dezember 2000 (online)

  als PDF herunterladen  Lizenzen und Reprints Alle Artikel dieser Rubrik

Synthesis of a new conformationally constrained dimeric building-block containing a cyclopropyl-amide functionality is described. Potential application of this dimer for antisense oligonucleotides is discussed.

Antisense - Cyclopropyl nucleoside - Michael reaction - Amide backbone - Sugar-backbone conformation