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Synlett 1996; 1996(7): 620
DOI: 10.1055/s-1996-5577
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Synthesis of Amphiphilic Derivatives of N-Methyldiethanolamine. Cationic Lipids 51

Igor Solodin, Carolyn S. Brown, Timothy D. Heath*
  • *School of Pharmacy, University of Wisconsin, 425 N. Charter St., Madison, WI 53706, USA
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Publication Date:
31 December 2000 (online)

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The preparation of a series of cationic lipids based on N-methyldiethanolamine is described. It includes O,O’-dialkylation or O,O’-diacylation of N-methyldiethanolamine with subsequent quaternization of the nitrogen atom to form the lipid head polar group.

cationic lipids - cationic liposomes - gene transfection - drug delivery - N-methyldiethanolamine derivatives