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Synlett 1997; 1997(11): 1306-1308
DOI: 10.1055/s-1997-1004
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Asymmetric Hydrogenation of α, β, and γ-Aminoketones Catalyzed by Cationic Rhodium(I){AMPP} Complexes

Marc Devocelle, Francine Agbossou* , André Mortreux
  • *Laboratoire de Chimie Organique Appliquée de l’ENSCL Lille, URA Centre National de la Recherche Scientifique 402, Université des Sciences et Technologies de Lille, BP 108, 59652 Villeneuve d’Ascq cedex, France, FAX 33 3 21 43 65 85; e-mail agbossou@pop.univ-lille1.fr.
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Publication History

Publication Date:
31 December 2000 (online)

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The chiral cationic rhodium aminophosphine-phosphinite complexes 4-6 were applied successfully in the asymmetric hydrogenation of α- (7-9), β- (10, 11) and γ- (12) aminoketone hydrochloride derivatives leading to the corresponding aminoalcohols in up to 97, 93, and 92 % enantiomeric excesses for the three types of substrates respectively.

asymmetric hydrogenation - aminophosphine-phosphinite - rhodium(I) - aminoketones - aminoalcohols