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Synlett 1997; 1997(11): 1233-1234
DOI: 10.1055/s-1997-1029
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Direct N3 Alkylation of Uracil and Derivatives via n1-[2-(trimethylsilyl)ethoxymethyl] Protection

L. Arias, A. Guzmán, S. Jaime-Figueroa, F. J. Lopez* , D. J. Morgans Jr., F. Padilla, A. Pérez-Medrano, C. Quintero, M. Romero, L. Sandoval
  • *Roche Bioscience, 3401 Hillview Ave, Palo Alto, CA 93404, USA, Fax (650) 852-1875; francisco.lopez-tapia@roche.com
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Publication History

Publication Date:
31 December 2000 (online)

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Protection at N1 position of uracil and uracil analogs as 2-(trimethylsilyl)ethoxymethyl derivatives permits the clean alkylation at N3. These protected uracils are quite stable in a wide range of pH.

n1-uracil protection - regioselectivity - 1-[2-(trimethylsilyl)ethoxymethyl]-3-alkyluracils - pH stability - 3-alkyluracils