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Synlett 1997; 1997(9): 1111-1113
DOI: 10.1055/s-1997-1550
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A Unified Procedure for Diastereo- and Enantiocontrolled Construction of Compactin Lactone and Calcitriol Enyne

Mitsuru Oizumi, Michiyasu Takahashi, Kunio Ogasawara*
  • *Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-77, Japan, Fax +81-22-217-6845; email konol@mail.cc.tohoku.ac.jp
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Publikationsdatum:
31. Dezember 2000 (online)

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A unified diastereo- and enantiocontrolled entry into compactin lactone, an essential structural moiety for the biological activity of compactin, and calcitriol enyne, an A-ring precursor of calcitriol, has been developed by use of the same stereocontrol procedure starting from enantiomeric epichlorohydrins.

compactin lactone - calcitriol enyne - optically active epichlorohydrin - optically active O-benzylglycidol - diastereo- and enantiocontrolled synthesis