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Synlett 1997; 1997(SI): 521-522
DOI: 10.1055/s-1997-6138
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One-Pot Conversion of α-Thioureido Esters to Imidazol-2-ones and Imidazole-2-thiones

Jay A. Markwalder* , Richard S. Pottorf, Steven P. Seitz
  • *Chemical and Physical Sciences Department, DuPont Merck Pharmaceutical Company, DuPont Experimental Station, Wilmington, DE 19880-0500
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Publication History

Publication Date:
31 December 2000 (online)

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4-Hydroxyimidazolidin-2-ones and 4-hydroxyimidazolidine-2-thiones are obtained by treatment of N-(aminocarbonyl)-α-amino esters and N-(aminothiocarbonyl)-α-amino esters with diisobutylaluminum hydride (DIBAH). These substances are transformed to imidazol-2-ones and imidazole-2-thiones upon acidic workup.

imidazol-2-one - imidazole-2-thione - angiotensin II